Production and Quality Control of 18F-PSMA for imaging of Prostate Cancer

، صفحه 0-0 (1)
عنوان دوره: اولین دوره بین المللی و بیست و هشتمین دوره ملی (1400)
We report an automatic radiosynthesis of fluorine-18-labelled prostate-specific membrane antigen (PSMA) -ligand [18F]PSMA-1007 as the next generation radiofluorinated for routine production in large scale. A synthera V2 module with in-house prepared materials and method were optimized to produce and purify of 18F-PSMA radiopharmaceutical. PSMA-1007 was synthesis in Kimia Pazhooh Dorsa company and after characterization tests is used for labeling with 18F. Phosphate buffered saline and sodium L-ascorbate were used for pH adjustment and stability of final product. Quality control tests were done base on European Pharmacopoeia (EP) Reference Standard. The purity of final product was more than 98% and stability test was done for 6 hours after production and shows a good stability during these duration.
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